Up Next. Pentose phosphate pathway activation has been suggested as a mechanism by which dysregulated NRF2–KEAP1 signaling promotes cellular proliferation and tumorigenesis . Pentose phosphate pathway. Pentose Phosphate Pathway Generation of NADPH and Pentoses Overview Function NADPH production Reducing power carrier Synthetic pathways Role as cellular antioxidants ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3b5ef9-MzQ0M The pentose phosphate pathway is also important in the red blood cell, where NADPH is required to maintain an adequate pool of reduced glutathione, which is used to remove hydrogen peroxide.. As shown in Figure 5.15, the tripeptide glutathione (y-glutamyl-cysteinyl-glycine) is the reducing agent for glutathione peroxidase, which reduces H2O2 to H2O and O2. Sort by: Top Voted. Is the Pentose Phosphate Pathway just about making ribose sugars from glucose? sugars) via the Pentose Phosphate Pathway. Carbohydrate metabolism questions. The pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. The Hexose Monophosphate Shunt is also known as “Pentose Phosphate Pathway” (PPP).This is an alternative Glucose oxidation pathway.The hexose monophosphate pathway is used for the production of NADPH from NADP.. 9.25). pentose-phosphate pathway hexose monophosphate shunt phosphogluconate pathway O SlideShare utiliza cookies para otimizar a funcionalidade e o desempenho do site, assim como para apresentar publicidade mais relevante aos nossos usuários. Cellular respiration introduction. Cellular respiration introduction. The PPP serves a vital role in regulating cancer cell growth and involves many enzymes. Our mission is to provide a free, world-class education to anyone, anywhere. Next lesson. The NADPH is required for biosynthetic reactions such as fatty acid synthesis, cholesterol synthesis, drug reduction, and as a cofactor for some non-synthetic enzymatic reactions. There are two different phases in the pathway. Transcription factor NRF2 [NFE2L2, nuclear factor (erythroid-derived-2)-like 2] is known as a major sensor of oxidative stress in the cell. https://es.slideshare.net/sujitghosh5/pentose-phosphate-pathway-114189364 Glucose-6-phosphate dehydrogenase and a lactonase catalyze the first committed step of the oxidative pentose phosphate pathway which is a strategic control point. The pentose phosphate pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its oxidative branch and leads to the production of a reduced form of nicotinamide adenine dinucleotide phosphate and nucleic acid. The direct degradation of glucose is achieved in two phases: The first one consists of the oxidative conversion of glucose-6-P to pentose phosphates and the second non-oxidative phase involves the regeneration of glucose-6-phosphate from pentose phosphate, while glucose-6-phosphate enters the cycle again (Fig. (1) Important for biosynthetic pathways using NADPH, and (2) a high cytosolic reducing potential from NADPH is sometimes required to advert oxidative damage by radicals, e.g., O 2-and H—O The oxidative pentose phosphate pathway converts between 15 and 30% of hexose phosphate to glyceraldehyde-3-phosphate and CO 2 in pea and spinach chloroplasts. This pathway, which requires the presence of oxygen, is called pentose phosphate pathway (PPP) or hexose monophosphate shunt (HMS). Krebs (citric acid) cycle and oxidative phosphorylation.

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