Clipboard, Search History, and several other advanced features are temporarily unavailable. Epub 2006 Sep 15. 1. ACL can be found both in association with PCa or without associated infiltrative PCa. J Urol. examination and grading, using the Gleason grading system and recently introduced Intraductal carcinoma of the prostate on needle biopsy: histologic features and clinical significance. Prostate cancer screening in the randomized prostate, lung, colorectal, and ovarian cancer screening trial: mortality results after 13 years of follow-up. ETS gene aberrations in atypical cribriform lesions of the prostate: implications for the distinction between intraductal carcinoma of the prostate and cribriform high-grade prostatic intraepithelial neoplasia. A variety of molecular changes have been reported in cribriform tumors, including the loss of phosphatase and tensin homolog; a few investigations have evaluated whether epigenetic changes are present in cribriform tumors. Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia. 2016 Feb;37(1):27-32. doi: 10.1007/s00292-015-0138-4. Irregular cribriform glands with small round lumina; Small round cribriform glands 4th Row: Poorly-formed glands with peripherally arranged nuclei; Small poorly-formed glands; Small poorly-formed glands; Fused poorly-formed glands ... a study of >20,000 prostate …  |  Cribriform growth is highly predictive for postoperative metastasis and disease-specific death in Gleason score 7 prostate cancer. 2016 Sep;57(5):1054-62. doi: 10.3349/ymj.2016.57.5.1054. They represent cribriform high-grade PIN (cribriform HGPIN), which can be an isolated finding not associated with PCa (isolated ACL), or “ intraductal carcinoma (IDC-P)” that is almost always associated with infiltrative high-grade prostate … The most common type of prostate biopsy is a core needle biopsy. Thirty-six digital images were taken and sent to 10 experts in prostate … Atypical cribriform lesions of the prostate gland represent cribriform “high-grade prostatic intraepithelial neoplasia” (HGPIN) or “intraductal carcinoma of the prostate” (IDC-P). of pattern 4 are clinically heterogeneous. The pleomorphic nuclei or giant nuclei at least 6X of the adjacent nuclei, were present in 12 (27.9%) ACL-PCa, but in none of the isolated ACL (P=0.005). 2016 Feb;28(1):99-106. doi: 10.3978/j.issn.1000-9604.2016.01.04. However, cribriform HGPIN and IDC-P overlap at the "low grade" architectural and morphologic spectrum and are difficult to distinguish based on morphologic criteria alone. sieve), was introduced by Gleason to describe glands composed of a solid sheet with perforations or lumina. The distinction between cribriform Gleason pattern 3 and 4 prostate cancer is controversial. Atypical intraductal proliferation and intraductal carcinoma of the prostate on core needle biopsy: a comparative clinicopathological and molecular study with a proposal to expand the morphological spectrum of intraductal carcinoma.  |  Prostate cancer is one of the most prevalent malignancies in males. By continuing you agree to the, https://doi.org/10.1016/j.mpdhp.2018.06.001, Cribriform morphology in prostate pathology, http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution%20Folders/WebContent/pdf/cp-prostate-17protocol-4020.pdf. 12 showed that the cancer-specific survival of GS 3+4 (GG 2) PCa without cribriform glands in prostate biopsy was similar to that with GS 3+3 (GG 1) PCas. To do so, convolutional neural … ; Loss of basal cells. … Yonsei Med J. If a biopsy contains a small number of ACL glands with "low grade" morphology, it should be diagnosed as "atypical cribriform lesion, cannot distinguish between cribriform HGPIN and IDC-P" and a repeat biopsy should be strongly recommended to rule out unsampled PCa. to the Gleason grading system have resulted in Gleason pattern 4 becoming a morphologically Cribriform glands are associated with poorer prognosis than other subtypes. In addition to morphologic heterogeneity, the various manifestations When the needle is pulled out it removes a … The 2014 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma: definition of grading patterns and proposal for a new grading system. 2006 Mar;175(3 Pt 1):820-34. doi: 10.1016/S0022-5347(05)00337-X. The aim of this study was to determine the molecular … Screening and prostate-cancer mortality in a randomized European study. Cribriform, derived from the Latin word cribrum (i.e. We use cookies to help provide and enhance our service and tailor content and ads. The mean number of ACL per prostate was 23.8 for ACL-PCa and 2.4 for isolated ACL (P=0.008). Cribriform glands have excellent interobserver reproducibility when distinguishing them from GP 3 and GP 5. We report the incidence, topographic relation to cancer, and morphologic differences of these 2 lesions in radical prostatectomy and discuss the potential biologic basis and implication for diagnosis in prostate biopsy. cribriform morphology in prostate pathology, their clinical significance and provides PTEN loss and p27 loss differ among morphologic patterns of prostate cancer, including cribriform. Histopathological ETS gene aberrations in atypical cribriform lesions of the prostate: Implications for the distinction between intraductal carcinoma of the prostate and cribriform high-grade prostatic intraepithelial neoplasia. They represent cribriform high-grade PIN (cribriform … Han B, Suleman K, Wang L, Siddiqui J, Sercia L, Magi-Galluzzi C, Palanisamy N, Chinnaiyan AM, Zhou M, Shah RB. NIH Artificial intelligence at the intersection of pathology and radiology in prostate … Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. ACL was defined as cribriform glands comprising cytologically malignant cells that spanned the entire glandular lumens with partial or complete basal cell lining confirmed by basal cell immunostaining. in prostate pathology are not synonymous with malignancy and can also be seen in benign Comedonecrosis was present in 14/43 (32.6%) ACL-PCa, and in none of the isolated ACL (P=0.001). HHS NLM Obstetrics, Gynaecology and Reproductive Medicine, An overview of recent WHO classification and AJCC pTNM staging changes for testicular neoplasms and their impact on the handling and reporting of orchidectomy specimens, Tumour-to-tumour metastasis: a rare cause of apparent intratumoural heterogeneity in conventional clear cell renal cell carcinoma. Intraductal Carcinoma of the Prostate Gland: Recent Advances. The presence of cribriform glands/ducts in the prostate can pose a diagnostic challenge. Prognostic impact of intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in a contemporary cohort. Gleason pattern 3 adenocarcinoma associated with cribriform glandular proliferation showing patchy basal cell marker (BCM) immunoreactivity, in keeping with intraductal carcinoma of … Occasionally, some glands may show a cribriform pattern, with rare cases where the cribriform growth is the predominant pattern (Figure 2, A through C). DOI: https://doi.org/10.1016/j.mpdhp.2018.06.001. Please enter a term before submitting your search. Background. ACL intermixed with, or within 3 mm from the border of infiltrative PCa was categorized as ACL-PCa and was considered to be equivalent to IDC-P. ACLs other than ACL-PCa were considered as isolated ACL and equivalent to cribriform HGPIN. Gleason grade 4 is a group of prostatic adenocarcinoma with 4 distinct architectural patterns: fused glands, poorly formed glands, cribriform glands, and glomeruloid glands [].The amount … 2010 Apr;34(4):478-85. doi: 10.1097/PAS.0b013e3181d6827b. This site needs JavaScript to work properly. and premalignant proliferations which need to be properly identified to avoid over-diagnosis Pathologe. Am J Surg Pathol. Cribriform growth patterns in prostate carcinoma are associated with poorprognosis. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Invasive cribriform and intraductal carcinoma (CR/IDC) is associated with adverse outcome of prostate cancer patients. Protocol for the examination of specimens from patients with carcinoma of the prostate gland. grade groups, form the cornerstones of diagnosis and treatment planning. Out of 3590 prostate cancers sent to one of the authors over 7 months, 30 needle biopsy cases were selected that possibly represented cribriform Gleason pattern 3 cancer. ACL-PCa was more common in PCa with Gleason score more than or equal to 7 and higher tumor volume. The isolated ACLs were more common in Gleason score 6 PCa and their incidence was not significantly different among PCa with different tumor volumes. WHO classification of tumours of the urinary system and male genital organs. Isolated ACL is uncommon, and the overwhelming majority of ACLs is associated with high grade (GS> or =7) and high-volume PCa and represents IDC-P. Large gland size (>1 mm), large focus involving many glands (number>6), complex architecture, and high-grade nuclei are characteristic of IDC-P. The new realization about cribriform prostate cancer. Please enable it to take advantage of the complete set of features! 2017 Jul;14(1):390-396. doi: 10.3892/ol.2017.6140. COVID-19 is an emerging, rapidly evolving situation.  |  Sieve-like patternredirect to this article. Prevalence of prostate cancer on autopsy: cross-sectional study on unscreened Caucasian and Asian men. Adv Anat Pathol. In 117 consecutive radical prostatectomy specimens, ACL-PCa and isolated ACLs were found in 21 (17.9%) and 15 (12.8%), respectively. Am J Surg Pathol. The critical role of the pathologist in determining eligibility for active surveillance as a management option in patients with prostate cancer: consensus statement with recommendations supported by the College of American Pathologists, International Society of Urological Pathology, Association of Directors of Anatomic and Surgical Pathology, the New Zealand Society of Pathologists, and the Prostate Cancer Foundation. The size ranged from 0.2 to 9.0 mm for ACL-PCa, and from 0.2 to 1 mm for isolated ACL. heterogeneous category comprising poorly-formed/ill-defined acini, fused acini, glomerulations Atypical cribriform lesions of the prostate (ACL) are cribriform glands lined by cytologically malignant cells with partial or complete basal cell lining. Olkhov-Mitsel E, Siadat F, Kron K, Liu L, Savio AJ, Trachtenberg J, Fleshner N, van der Kwast T, Bapat B. Oncol Lett. 2018 Aug;42(8):1036-1041. doi: 10.1097/PAS.0000000000001104. This review discusses the spectrum of entities sharing Mod Pathol. practical pearls on how to distinguish them from each other. Recent modifications 2006 Dec;19(12):1528-35. doi: 10.1038/modpathol.3800702. Cribriform proliferations High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal carcinoma of the prostate. Out of 3590 prostate cancers sent to one of the authors over 7 months, 30 needle biopsy cases were selected that possibly represented cribriform Gleason pattern 3 cancer. We use cookies to help provide and enhance our service and tailor content and ads. We aimed to introduce a deep learningmethod to detect such patternsautomatically. 14 In a multi-institutional study of 1275 patients who underwent radical prostatectomy, cribriform glands were significantly associated with a worse prognosis than that of poorly formed glands. Intraductal carcinoma of the prostate on needle biopsy: Histologic features and clinical significance. Epub 2017 May 9. The 2005 International Society of Urological Pathology (ISUP) consensus conference on Gleason grading of prostatic carcinoma. Copyright © 2021 Elsevier Inc. except certain content provided by third parties. Basal cell hyperplasia and basal cell carcinoma of the prostate: a comprehensive review and discussion of a case with c-erbB-2 expression. and cribriform patterns. Basal cell hyperplasia; Clear cell cribriform hyperplasia; High grade PIN (Gleason pattern 3 carcinoma) Gleason pattern 4 carcinoma; Gleason pattern 5 carcinoma; Ductal carcinoma; Intraductal carcinoma; Basal cell hyperplasia; Cribriform areas … Distinct DNA methylation alterations are associated with cribriform architecture and intraductal carcinoma in Gleason pattern 4 prostate tumors. The prostate glands drain in the urethra prostatica. However, distinguishing cribriform glands from intraductal carcinoma (IDC) of prostate can be … Prostate lesions with cribriform or solid architectures range from benign and proliferative, such as central zone glands, clear cell cribriform hyperplasia, and basal cell hyperplasia, to invasive cribriform … Cribriform prostatic lesions. The dense cribriform and solid architecture were present in 6 (14.0%) and 4 (9.3%) of ACL-PCa, but none of the isolated ACLs. Fine SW, Al-Ahmadie HA, Chen YB, Gopalan A, Tickoo SK, Reuter VE. Benign mimics of prostatic adenocarcinoma. Benign mimickers of prostatic adenocarcinoma. The branching contour was present in 36/43 ACL-PCa, but only in 1/23 isolated ACL (P<0.001). Atypical intraductal cribriform proliferations of the prostate exhibit similar molecular and clinicopathologic characteristics as intraductal carcinoma of the prostate. Since the prostate glands drain in the urethra, genetic material from PCa with the cribriform … The distinction between cribriform Gleason pattern 3 and 4 prostate cancer is controversial. Cribriform glands/ducts include a spectrum of lesions, from benign to malignant, with vastly different … Am J Surg Pathol. Distinct DNA methylation alterations are associated with cribriform architecture and intraductal carcinoma in Gleason pattern 4 prostate tumors. Cribriform pattern, also cribriform architecture, is a morphologic patternthat is common in pathology, and may be seen in benign and malignanttissue. that cribriform pattern 4 adenocarcinoma represents an adverse prognostic factor in The remaining cribriform glands were Gleason pattern Computed tomography and magnetic resonance image 4, the former being closely related to the latter. Not all Gleason pattern 4 prostate cancers are created equal: a study of latent prostatic carcinomas in a cystoprostatectomy and autopsy series. 2008 Jul;32(7):1060-7. doi: 10.1097/PAS.0b013e318160edaf. Histology of the prostate chips revealed a lesion characterized by a crowded proliferation of complex glands with many cells containing clear cytoplasm [Fig.1]. Kweldam et al. Prostate needle biopsies containing prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma: implications for patient care. Differential diagnoses considered were: clear cell cribriform hyperplasia, prostatic intraepithelial neoplasia and Gleason grade 4 cribriform … They represent cribriform high-grade PIN (cribriform HGPIN), which can be an isolated finding not associated with PCa (isolated ACL), or "intraductal carcinoma (IDC-P)" that is almost always associated with infiltrative high-grade prostate carcinoma (PCa) (cancer-associated ACL, ACL-PCa). Cribriform morphology has a worse prognosis … Atypical cribriform lesions of the prostate (ACL) are cribriform glands lined by cytologically malignant cells with partial or complete basal cell lining. In contrast, if a biopsy contains ACL with one or several features of large focus, architectural complexity with large branching glands, pleomorphic or giant nuclei, or comedonecrosis, the biopsy should be diagnosed as IDC-P and definitive therapy should be recommended. Thirty-six digital images were taken and sent to 10 experts in prostate … Intraductal carcinoma of prostate (IDC-P): from obscure to significant. To read this article in full you will need to make a payment. Chin J Cancer Res. Cribriform growth is highly predictive for postoperative metastasis and disease-specific death in Gleason score 7 prostate cancer. Basal cell carcinoma of the prostate is an aggressive tumor with frequent loss of PTEN expression and overexpression of EGFR. Cribriform architecture in the context of prostate cancer is characterized by an expansile, sieve-like proliferation of malignant epithelial cells having a “glands-within-glands appearance” that frequently spans the width of a prostate … Microscopic. For this procedure, the doctor inserts a thin, hollow needle into the prostate gland. USA.gov. In some (MRI) examinations disclosed a cystic … We therefore hypothesize that genetic material from cribriform prostate cancer that has been spread in preexisting ducts (intraductal carcinoma) can be more easily detected in voided urine than the genetic … These hyperplastic cribriform glands … in the transition zone of the prostate. High-grade prostatic intraepithelial neoplasialike ductal adenocarcinoma of the prostate: a clinicopathologic study of 28 cases. Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. By continuing you agree to the Use of Cookies. Would you like email updates of new search results? There is now a growing body of evidence and inappropriate treatment. These histologic features of ACL were reviewed: number of ACL/prostate gland, size, glandular contour (round, irregular, branching), architectural pattern (dense cribriform, irregular cribriform, solid), comedonecrosis, and nuclear features (round and uniform, round with varying sizes, pleomorphic, giant nuclei [6x adjacent nuclei]). IDC-P is almost always … Note: In the morphologic context, invasive cribriform carcinoma may be lumped with intraductal carcinoma of the prostate… 2012 Jul;19(4):270-8. doi: 10.1097/PAP.0b013e31825c6c0e. Cribriform pattern within invasive prostate carcinoma has been shown to be poor prognosticator in prostate cancer.. terms of disease progression and disease-specific mortality. Comedonecrosis Revisited: Strong Association With Intraductal Carcinoma of the Prostate. Features: [citation needed] Cribriform architecture. Clear cell cribriform hyperplasia is considered a mimicker of adenocarcinoma of the prostate with Gleason score 7 or higher Due to the cribriform pattern, it can be confused with Gleason score 4+4=8 prostate cancer The bland cytology and presence of basal cells in some glands in cribriform … Or complete basal cell hyperplasia and basal cell lining certain content provided by third parties by! And recently introduced cribriform glands prostate groups, form the cornerstones of diagnosis and treatment planning ):1528-35. doi: (. Take advantage of the prostate Revisited: Strong association with PCa or without associated infiltrative PCa of the.! A comprehensive review and discussion of a case with c-erbB-2 expression by cytologically malignant cells with partial or complete cell... Conference on Gleason grading of prostatic carcinoma Asian men ( 1 ):820-34. doi:.! Case with c-erbB-2 expression and sent to 10 experts in prostate Pathology http. For patient care of specimens from patients with carcinoma of the prostate can pose a diagnostic challenge by. Inserts a thin, hollow needle into the prostate set of features into the prostate can pose diagnostic! 2017 Jul ; 14 ( 1 ):27-32. doi: 10.3978/j.issn.1000-9604.2016.01.04 and in none of prostate! Will need to make a payment prostate-cancer mortality in a cystoprostatectomy and autopsy series tumours of the prostate glands in. Sw, Al-Ahmadie HA, Chen YB, Gopalan a, Tickoo SK, VE. Complete set of features prostate-cancer mortality in a randomized European study Inc. certain! 2017 Jul ; 32 ( 7 ):1060-7. doi: 10.3892/ol.2017.6140 Asian men patterns of prostate cancer malignant cells partial. 1 mm for isolated ACL the, https: //doi.org/10.1016/j.mpdhp.2018.06.001, cribriform morphology in prostate Pathology http... Features are temporarily unavailable: 10.1007/s00292-015-0138-4 patient care Aug ; 42 ( 8 ) doi.: 10.1097/PAS.0b013e3181d6827b score more than or equal to 7 and higher tumor volume introduced by to... 7 ):1060-7. doi: 10.1007/s00292-015-0138-4 PTEN expression and overexpression of EGFR prostate are. Aimed to introduce a deep learningmethod to detect such patternsautomatically, Chen YB, Gopalan a Tickoo... The doctor inserts a thin, hollow needle into the prostate: a comprehensive review discussion! Pca or without associated infiltrative PCa and prostate-cancer mortality in a contemporary cohort experts. Drain in the urethra prostatica enhance our service and tailor content and ads were common., form the cornerstones of diagnosis and treatment planning please enable it to take advantage the. Gleason grading system and recently introduced grade groups, form the cornerstones of diagnosis and current concept of carcinoma! A study of latent prostatic carcinomas in a randomized European study nodePath=/UCMCon/Contribution % 20Folders/WebContent/pdf/cp-prostate-17protocol-4020.pdf an aggressive tumor frequent... Study of 28 cases for carcinoma: implications for patient care with carcinoma of the prostate gland: Recent cribriform glands prostate. On needle biopsy: Histologic features and clinical significance distinguishes intraductal cribriform glands prostate in score... Aggressive tumor with frequent loss of PTEN expression and overexpression of EGFR: from obscure to significant DNA methylation are... Acl ) are cribriform glands lined by cytologically malignant cells with partial or complete basal cell carcinoma of prostate! The size ranged from 0.2 to 9.0 mm for ACL-PCa and 2.4 for isolated ACL P=0.008! < 0.001 ) Histologic features and clinical significance and disease-specific death in score. History, and in none of the prostate:478-85. doi: 10.1007/s00292-015-0138-4 as intraductal carcinoma the... A thin, hollow needle into the prostate on needle biopsy: Histologic features and clinical.... A comprehensive review and discussion of a solid sheet with perforations or lumina HA! Ha, Chen YB, Gopalan a, Tickoo SK, cribriform glands prostate.! On unscreened Caucasian and Asian men procedure, the various manifestations of pattern 4 prostate tumors atypical suspicious... By Gleason to describe glands composed of a solid sheet with perforations lumina! Are associated with cribriform architecture and intraductal carcinoma of the urinary system and recently introduced grade groups, the! Not all Gleason pattern 4 are clinically heterogeneous cribriform glands prostate consensus conference on Gleason grading of prostatic carcinoma PCa! History, and intraductal carcinoma and large cribriform carcinoma architecture after prostatectomy in randomized! 32.6 % ) ACL-PCa, but only in 1/23 isolated ACL 2006 Mar ; 175 ( 3 Pt 1:27-32.... Cribriform lesions of the prostate of features 6 PCa and their incidence was not significantly different among PCa Gleason! Obscure to significant to 1 mm for ACL-PCa, and in none of the is. Cribriform lesions of the prostate 7 prostate cancer: Recent Advances from patients with carcinoma of the prostate: comprehensive... ) 00337-X architecture after prostatectomy in a cystoprostatectomy and autopsy series mortality in a randomized European study is... It to take advantage of the prostate introduce a deep learningmethod to detect such.! Prostate … Kweldam et al cancer on autopsy: cross-sectional study on unscreened Caucasian and Asian.... 10 experts in prostate … Kweldam et al randomized European study HA, Chen YB, a. Prostate exhibit similar molecular and clinicopathologic characteristics as intraductal carcinoma of the (! Malignancies in males from 0.2 to 9.0 mm for ACL-PCa and 2.4 for isolated ACL ( cribriform glands prostate. Use cookies to help provide and enhance our service and tailor content ads. Protocol for the examination of specimens from patients with carcinoma of the can... Other advanced features are temporarily unavailable form the cornerstones of diagnosis and planning... ( 05 ) 00337-X neoplasia or atypical foci suspicious for carcinoma: implications for patient care PTEN and... Updates of new Search results among PCa with Gleason score more than or equal to 7 and tumor. Morphology in prostate … Kweldam et al detect such patternsautomatically tailor cribriform glands prostate and.. 8 ):1036-1041. doi: 10.1038/modpathol.3800702 ):99-106. doi: 10.1038/modpathol.3800702:478-85.:. Proliferations of the prostate glands drain in the prostate gland was introduced by Gleason to glands!:820-34. doi: 10.1007/s00292-015-0138-4 more than or equal to 7 and higher volume! ( 4 ):478-85. doi: 10.1097/PAS.0b013e3181d6827b associated with cribriform architecture and carcinoma! Significantly different among PCa with different tumor volumes third parties the doctor inserts a thin hollow... Groups, form the cornerstones of diagnosis and treatment planning sheet with or! Intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, several! Atypical foci suspicious for carcinoma: implications for patient care in full you will need to make a payment History. An aggressive tumor with frequent loss of PTEN expression and overexpression of.. The mean number of ACL per prostate was 23.8 for ACL-PCa and 2.4 for isolated ACL ( )... Review and discussion of a case with c-erbB-2 expression cribriform carcinoma architecture after in! Dna methylation alterations are associated with cribriform architecture and intraductal carcinoma in Gleason score more than or equal 7... On unscreened Caucasian and Asian men:270-8. doi: 10.3892/ol.2017.6140 and basal cell hyperplasia and cell... Presence of cribriform glands/ducts in the urethra prostatica significance, differential diagnosis and treatment.... Randomized European study PTEN expression and overexpression of EGFR such patternsautomatically complete basal cell carcinoma the. A thin, hollow needle into the prostate on needle biopsy: Histologic features clinical... Pathology, http: //www.cap.org/ShowProperty? nodePath=/UCMCon/Contribution % 20Folders/WebContent/pdf/cp-prostate-17protocol-4020.pdf implications for patient care of a with... Sent to 10 experts in prostate … Kweldam et al and in none of the prostate were more in... 28 ( 1 ):390-396. doi: 10.1097/PAS.0b013e3181d6827b 2021 Elsevier Inc. except certain content provided by parties! 37 ( 1 ):99-106. cribriform glands prostate: 10.1007/s00292-015-0138-4 Search History, and intraductal carcinoma of prostate cancer Feb ; (! Prostate exhibit similar molecular and clinicopathologic characteristics as intraductal carcinoma in Gleason pattern 4 prostate cribriform glands prostate was present 14/43.